Alkaline Diuresis in Treatment of Aspirin Poisoning

The treatment of salicylate poisoning using mannitol and forced alkaline diuresis.

1. A comparison has been made between alkaline mannitol diuresis and alkaline glucose diuresis in the treatment of salicylate poisoning during an 8 hr period. 2. Mannitol gave a higher rate of urine flow, but there was no significant difference in the rate of salicylate excretion. 3. Serum levels of sodium, potassium and calcium fell in both groups, mainly during the first 2 hr. The mean fall i...

Diuresis or urinary alkalinisation for salicylate poisoning?

Forty-four adults with aspirin poisoning were treated with oral fluids only, standard forced alkaline diuresis, forced diuresis alone, or sodium bicarbonate (alkali) alone. Alkali alone was at least as effective and possibly more effective than forced alkaline diuresis in enhancing salicylate removal. Unlike the diuresis regimens it did not cause fluid retention or biochemical disturbances. The...

Atropine Poisoning Treated by Forced Diuresis.

DUNLOP, D. M. (I963): Eighty-six Cases of Addison's Disease, Brit. med. J., ii, 887. FELix-DAvIEs, D. (1955): Addison's Disease Presenting as Loss of Weight without Pigmentation, Ibid., 48, 1023. FELLOWS, R. E., BUCHANAN, J. R., PETERSON, R. E., STOKES, P. E. (I:962): Chronic Primary Adrenal Insufficiency without Hyperpigmentation, New Engl. Y. Med., 267, 215. JENKINS, D., FORSHAM, P. H., LAIDL...

High frequency jet ventilation and aspirin poisoning.

ASPIRIN poisoning is responsible for over 200 deaths per annum in England and Wales. Forced alkaline diuresis is advocated to hasten renal elimination of the drug when plasma salicylate levels exceed 500 mg/l, whilst charcoal haemoperfusion is the treatment of choice when plasma salicylate levels exceed 900 mg/kg.' This severity of poisoning causes gross respiratory, metabolic and coagulation d...

Aspirin poisoning in children; a review of the literature.